If you navigate to eBay Integration > Configuration > Settings section, you can specify preferences for Global settings and configure the specificity of eBay Items management.
Please, take a time to review each configuration in details:
Main - contains specific configurations for eBay Items management;
Synchronization - allows determining whether the products should be updated on eBay automatically;
Parts Compatibility - allows specifying a Magento Attribute, where the ePID/k-Type values will be saved, as well as importing a custom base of compatible vehicles;
Interface - allows specifying global preferences on how the data should be displayed in your M2E Pro;
Magento Inventory - allows providing the global settings for Inventory and Product Price management;
Logs Clearing - contains settings for the automatic clearing of the logs records;
License - allows identifying which License Key and related to it information are associated with your current installation.